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CAS RN: 330808-88-3 | Product Number: V0174
Vardenafil Hydrochloride Trihydrate
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Purity: >95.0%(T)(HPLC)
Synonyms:
- 2-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one Hydrochloride Trihydrate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
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|
|---|---|---|---|---|---|
| 250MG |
NT$2,814
|
0 | 0 | Contact Us |
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| Product Number | V0174 |
Purity / Analysis Method 
|
>95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__3__2N__6O__4S·HCl·3H__2O = 579.12 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 330808-88-3 |
| Reaxys Registry Number | 15521289 |
| MDL Number | MFCD08458876 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Precipitation Titration) | min. 95.0 % |
| Water | 7.5 to 10.0 % |
| NMR | confirm to structure |
Properties (reference)
| Solubility in water | Slightly soluble |
| Solubility (slightly sol. in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | NJ6154000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2935.90-000 |
Application
Vardenafil: A Selective PDE5 Inhibitor
Vardenafil hydrochloride is a selective inhibitor of 3’,5’-cyclic guanosine monophosphate (cGMP) - specific phosphodiesterase type 5 (PDE5) which is the predominant PDE isoenzyme in human corpora cavernosa, as with sildenafil [S0986 (Citrate)].1,2) In addition, recently PDE5 inhibitors, including tadalafil, are widely used for the treatment of pulmonary arterial hypertension (PAH) which is a progressive disease that ultimately causes right heart failure and death.3) (The product is for research purpose only.)
References
- 1) The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil
- 2) Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil review of the literature (a review)
- 3) Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets
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