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CAS RN: 446859-33-2 | Product Number: R0224
RepSox
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Purity: >98.0%(HPLC)
Synonyms:
- ALK 5 Inhibitor II
- 2-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
- TGF-β RI Kinase Inhibitor II
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5MG |
NT$5,376
|
15 | 29 | It can be shipped in about 3-4 weeks after ordering | |
| 25MG |
NT$20,076
|
21 | 1 | It can be shipped in about 3-4 weeks after ordering |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | R0224 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__3N__5 = 287.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 446859-33-2 |
| Reaxys Registry Number | 9782770 |
| PubChem Substance ID | 468592794 |
| MDL Number | MFCD09037561 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 193.0 to 197.0 °C |
Properties (reference)
| Melting Point | 195 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2933.99-000 |
Application
TGF-β Type I Receptor Inhibitor
RepSox (1) is a cell permeable TGF-β type I receptor inhibitor. 1 shows inhibition properties on ALK5 as shown in Table 1 and less potent activity against 9 other related kinases, including p38 MAPK, JNK1, and GSK3 (IC50 > 16 μM).1) 1 promotes reprogramming of human and mouse embryonic fibroblasts to induced pluripotent stem cells (iPSCs).2,3) In addition, it was also reported that 1 induces human ESCs and iPSCs into glucagon-producing cells and insulin-producing cells, respectively.4,5)
References
- 1) Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-β type I receptor inhibitors
- 2) A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog
- 3) Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells
- 4) Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells
- 5) Production of functional glucagon-secreting α-cells from human embryonic stem cells
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