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CAS RN: 212631-79-3 | Product Number: P2174
PD 184352
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Purity: >98.0%(HPLC)
Synonyms:
- 2-(2-Chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
NT$9,640
|
7 | 1 | Contact Us | |
| 100MG |
NT$28,560
|
10 | 2 | Contact Us |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
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* The storage conditions are subject to change without notice.
| Product Number | P2174 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__4ClF__2IN__2O__2 = 478.66 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 212631-79-3 |
| Reaxys Registry Number | 10032343 |
| PubChem Substance ID | 468592581 |
| MDL Number | MFCD02683961 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 5.30 to 6.30 % |
| Melting point | 176.0 to 180.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 178 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2928.00-000 |
Application
PD184352: A Selective Inhibitor of Mitogen-Activated Protein Kinase (MAPK)
PD184352 (or Cl-1040) is an orally active and selective inhibitor of mitogen-activated protein kinase (MAPK or MAP kinase), a type of serine/threonine protein kinase.
References
- Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
- Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia
- CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK) (a review)
- The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (Cl-1040) selectively induces apoptosis in malignant schwannoma cell lines
Product Documents (Note: Some products will not have analytical charts available.)
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