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CAS RN: 338967-87-6 | Product Number: M3108
Mdivi-1
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Purity: >95.0%(HPLC)
Synonyms:
- 3-(2,4-Dichloro-5-methoxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-quinazolinone
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
NT$5,334
|
3 | 0 | It can be shipped in about 2 weeks after ordering | |
| 50MG |
NT$18,564
|
10 | 6 | It can be shipped in about 3-4 weeks after ordering |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | M3108 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__0Cl__2N__2O__2S = 353.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 338967-87-6 |
| Reaxys Registry Number | 23802926 |
| PubChem Substance ID | 354335750 |
| MDL Number | MFCD00974506 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
Properties (reference)
| Melting Point | 289 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2933.79-000 |
Application
Mdivi-1: A Selective Cell-Permeable Inhibitor of Mitochondrial Fission
Mitochondria play a key role in maintaining cellular metabolic homeostasis, and its fission and fusion play important roles in in several pathological conditions. Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp-1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders.
Mdivi-1 (mitochondrial division inhibitor 1) has been reported to inhibit selectively Drp-1 dependent fission with cell permeability. Inhibiting mitochondrial fission with Mdivi-1 has proven cytoprotective benefits in several cell types involved in a wide array of cardiovascular injury models. (The product is for research purpose only.)
Mdivi-1 (mitochondrial division inhibitor 1) has been reported to inhibit selectively Drp-1 dependent fission with cell permeability. Inhibiting mitochondrial fission with Mdivi-1 has proven cytoprotective benefits in several cell types involved in a wide array of cardiovascular injury models. (The product is for research purpose only.)
References
- Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization
- Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
- Small Molecule Inhibitors of Mitochondrial Division: Tools that Translate Basic Biological Research into Medicine (a review)
- Mitochondrial fusion by pharmacological manipulation impedes somatic cell reprogramming to pluripotency: new insight into the role of mitophagy in cell stemness (a review)
- Mitochondrial fission - a drug target for cytoprotection or cytodestruction? (a review)
PubMed Literature
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