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CAS RN: 101152-94-7 | Product Number: M2133
Milnacipran Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- cis-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide Hydrochloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 50MG |
NT$1,320
|
10 | 16 |
| 500MG |
NT$7,560
|
9 | 13 |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | M2133 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__2__2N__2O·HCl = 282.81 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 500MG-Glass Bottle with Plastic Insert (View image), 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 101152-94-7 |
| Related CAS RN | 92623-85-3 |
| Reaxys Registry Number | 6078861 |
| PubChem Substance ID | 125307702 |
| Merck Index (14) | 6194 |
| MDL Number | MFCD00901293 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 181 °C(dec.) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | GZ1014010 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2924.29-000 |
Application
Milnacipran hydrochloride: A Selective Serotonin Noradrenaline Reuptake Inhibitor (SNRI)
Milnacipran hydrochloride is a selective serotonin noradrenaline reuptake inhibitor (SNRI) which acts by inhibiting noradrenaline (norepinephrine) and serotonin (5-hydroxytrytamine; 5-HT) reuptake at presynaptic sites. Milnacipran has unique characteristics that distinguish it from the other SNRIs, venlafaxine [V0110] and duloxetine [D4223], such as inhibition of noradrenaline reuptake with approximately 3-fold higher potency in vitro than serotonin. Milnacipran has no significantt affinity for other neurotransmitter receptors, such as serotonergic, α- and β-adrenergic, muscarinic, histamine, dopamine, opioid, benzodiazepine, and γ-aminobutyric acid (GABA) receptors in vitro. Milnacipran does not inhibit the activity of human monoamine oxidases (MAO-A and MAO-B) or acetylcholinesterase. (The product is for research purpose only.)
References
- Selective serotonin/noradrenaline reuptake inhibitors (SNRIs). Pharmacology and therapeutic potential in the treatment of depressive disorders (a review)
- Neurochemical and behavioral characterization of Milnacipran, a serotonin and noradrenaline reuptake inhibitor in rats
- Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity
- High-performance liquid chromatographic method to screen and quantitate seven selective serotonin reuptake inhibitors in human serum
- A stability indicating U-HPLC method for milnacipran in bulk drugs and pharmaceutical dosage forms
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