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CAS RN: 53-86-1 | Product Number: I0655
Indomethacin

Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic Acid
- Indometacin
Product Documents:
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Product Number | I0655 |
Purity / Analysis Method | >98.0%(T)(HPLC) |
Molecular Formula / Molecular Weight | C__1__9H__1__6ClNO__4 = 357.79 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
Condition to Avoid | Light Sensitive |
CAS RN | 53-86-1 |
Reaxys Registry Number | 497341 |
PubChem Substance ID | 87561687 |
Merck Index (14) | 4968 |
MDL Number | MFCD00057095 |
Specifications
Appearance | White to Light yellow to Light orange powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Neutralization titration) | min. 98.0 % |
Melting point | 158.0 to 162.0 °C |
Solubility in hot Methanol | almost transparency |
Properties (reference)
Melting Point | 160 °C |
Solubility in water | Insoluble |
Degree of solubility in water | 0.937 mg/l 25 °C |
Solubility (soluble in) | Chloroform, Ether, Acetone, Ethanol, Methanol |
GHS
Pictogram |
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Signal Word | Danger |
Hazard Statements | H300 : Fatal if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
RTECS# | NL3500000 |
Transport Information:
UN Number | UN2811 |
Class | 6.1 |
Packing Group | I |
H.S.code* | 2933.99-000 |
Application
Reagent for gastropathy (gastric mucosal injury) model
References
- Oxidative stress involvement and gene expression in indomethacin-induced gastropathy
- Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury
- Y. Naito, T. Yoshikawa, N. Yoshida, M. Kondo, Dig. Dis. Sci. 1998, 43, 30S.
- Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease
Application
Studies on Inhibition of Cyclooxygenase (COX)
References
- A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
- NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2
- Inducible cyclooxygenase may have anti-inflammatory properties
- Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
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