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CAS RN: 26116-56-3 | Product Number: E1555
Erythromycylamine

Purity: >90.0%(qNMR)
Synonyms:
- (9S)-9-Amino-9-deoxoerythromycin
- 9(S)-Erythromycylamine
- (3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-10-Amino-6-[[(2S,3R,4S)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
Product Documents:
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Product Number | E1555 |
Purity / Analysis Method | >90.0%(qNMR) |
Molecular Formula / Molecular Weight | C__3__7H__7__0N__2O__1__2 = 734.97 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Frozen (-20°C) |
Store Under Inert Gas | Store under inert gas |
Condition to Avoid | Air Sensitive,Heat Sensitive |
Packaging and Container | 200MG-Glass Bottle with Plastic Insert (View image) |
CAS RN | 26116-56-3 |
Reaxys Registry Number | 4241492 |
MDL Number | MFCD00872156 |
Specifications
Appearance | White to Light yellow powder to crystal |
Purity(qNMR) | min. 90.0 % |
Specific rotation | -45.0 to -49.0 deg(C=1, CHCl3) |
NMR | confirm to structure |
Properties (reference)
Melting Point | 129 °C |
Degree of solubility in water | 1.22 g/l 20 °C |
GHS
Pictogram |
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Signal Word | Danger |
Hazard Statements | H318 : Causes serious eye damage. H410 : Very toxic to aquatic life with long lasting effects. |
Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P280 : Wear eye protection/ face protection. P391 : Collect spillage. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
RTECS# | KF4590000 |
Transport Information:
UN Number | UN3077 |
Class | 9 |
Packing Group | III |
H.S.code* | 2941.50-000 |
Application
Erythromycylamine: An Active Metabolite of a Macrolide Antibiotic Dirithromycin
Erythromycylamine is the major active metabolite of dirithromycin [D5495], derived from a macrolide antibiotic erythromycin [E0751].1) Erythromycylamine has excellent activity against Campylobacter, a type of bacteria that can cause diarrheal disease.2) (The product is for research purpose only.)
References
- 1) Synthesis and antimicrobial evaluation of dirithromycin (ASE 136; LY237216), a new macrolide antibiotic derived from erythromycin
- 2) Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides
- 3) Quantitative determination of erythromycylamine in human plasma by liquid chromatography-mass spectrometry and its application in a bioequivalence study of dirithromycin
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