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CAS RN: 14976-57-9 | Product Number: C3816
Clemastine Fumarate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (R)-2-[2-[(R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine Fumarate
- (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine (2E)-2-Butenedioate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 250MG |
NT$4,242
|
3 | 0 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | C3816 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__6ClNO·C__4H__4O__4 = 459.97 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic |
| Packaging and Container | 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 14976-57-9 |
| Reaxys Registry Number | 6472482 |
| MDL Number | MFCD00137486 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 171.0 to 175.0 °C |
| Specific rotation | +16.0 to +20.0 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 174 °C |
| Solubility in water | Insoluble |
| Solubility (insoluble in) | Diethyl ether |
GHS
Related Laws:
| RTECS# | UY0704600 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Clemastine Fumarate: A First-Generation Histamine H1 Receptor Antagonist
Clemastine fumarate is a first-generation histamine H1 receptor antagonist with anticholinergic properties and sedative side effects.1,2) Recently, there are reports that clemastine fumarate has ability to suppress nerve inflammation no matter in peripheral system or central nervous system. Therefore, clemastine fumarate is expected to an effective agent for neurodegeneration.3) (The product is for research purpose only.)
References
- 1) Antimuscarinic Effects of Antihistamines: Quantitative Evaluation by Receptor-Binding Assay
- 2) Identifying mechanism-of-action targets for drugs and probes
- 3) Drug repurposing: Clemastine fumarate and neurodegeneration (a review)
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