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CAS RN: 302964-08-5 | Product Number: C3675
2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
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![2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide")
Purity: >98.0%(HPLC)
Synonyms:
- N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
NT$1,260
|
1 | 3 | Contact Us | |
| 5G |
NT$3,822
|
9 | 0 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | C3675 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__3Cl__2N__5OS = 394.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 302964-08-5 |
| Reaxys Registry Number | 9869700 |
| PubChem Substance ID | 468591222 |
| MDL Number | MFCD11045075 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 96.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 280 °C |
| Maximum Absorption Wavelength | 320 nm (MeOH) |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.10-000 |
Application
A Key Synthetic Intermediate of Dasatinib
This product is a key synthetic intermediate of dasatinib (BMS-354825) which is a dual BCR/ABL and Src family tyrosine kinase inhibitor used for the treatment of chronic myelogenous leukemia (CML).
References
- Discovery of N-(2-Chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent AntitumorActivity in Preclinical Assays
- 2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure-Activity Relationship Studies toward the Discovery of N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a Potent pan-Src Kinase Inhibitor
- Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes
- Trace level determination and quantification of potential genotoxic impurities in dasatinib drug substance by UHPLC/infinity LC
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