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CAS RN: 184475-71-6 | Product Number: C3647
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol
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Purity: >98.0%(T)(HPLC)
Synonyms:
- O-Desmorpholinopropyl Gefitinib
- 4-(3-Chloro-4-fluoroanilino)-6-hydroxy-7-methoxyquinazoline
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
NT$1,134
|
8 | 34 | Contact Us | |
| 5G |
NT$3,822
|
10 | 35 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | C3647 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__1ClFN__3O__2 = 319.72 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 184475-71-6 |
| Reaxys Registry Number | 8928756 |
| PubChem Substance ID | 468591210 |
| MDL Number | MFCD09908046 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 293 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2933.59-000 |
Application
A Key Synthetic Intermediate of Gefitinib
This product is a key synthetic intermediate of gefitinib (ZD1839) [G0546] which is a potent and selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.
References
- Studies leading to the identification of ZD1839 (iressa): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer
- Improved synthesis of substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib, erlotinib and gefitinib
- Synthesis and in vitro antitumor activities of novel 4-anilinoquinazoline derivatives
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