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CAS RN: 35825-57-1 | Product Number: C3363
Cryptotanshinone
Purity: >97.0%(HPLC)
Synonyms:
- Tanshinone C
- (R)-1,2,6,7,8,9-Hexahydro-1,6,6-trimethylphenanthro[1,2-b]furan-10,11-dione
Product Documents:
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Product Number | C3363 |
Purity / Analysis Method | >97.0%(HPLC) |
Molecular Formula / Molecular Weight | C__1__9H__2__0O__3 = 296.37 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Refrigerated (0-10°C) |
Condition to Avoid | Heat Sensitive |
CAS RN | 35825-57-1 |
Reaxys Registry Number | 5445400 |
PubChem Substance ID | 354334480 |
MDL Number | MFCD07636810 |
Specifications
Appearance | Orange to Brown powder to crystal |
Purity(HPLC) | min. 97.0 area% |
Specific rotation [a]20/D | -28.0 to -32.0 deg(C=0.5,MeOH) |
NMR | confirm to structure |
Properties (reference)
Melting Point | 192 °C |
Specific Rotation | -30° (C=0.5,MeOH) |
Maximum Absorption Wavelength | 263 nm |
GHS
Pictogram | |
Signal Word | Danger |
Hazard Statements | H301 : Toxic if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
Transport Information:
UN Number | UN1544 |
Class | 6.1 |
Packing Group | III |
H.S.code* | 2932.99-000 |
Application
Hypoxia inducible factor (HIF) research / Hypoxia inducible factor (HIF) inhibitor
Reference
- Abietane Diterpenes from Salvia miltiorrhiza Inhibit the Activation of Hypoxia-Inducible Factor-1
Application
Cryptotanshinone: A Quinoid Diterpene with Versatile Pharmacological Effects
Cryptotanshinone, a quinoid diterpene, is one of the major tanshinones isolated from the roots of the plant Salvia miltiorrhiza Bunge. Tanshinones has been widely used in traditional Chinese medicine for treatment of a variety of diseases. Cryptotanshinone has been reported that cryptotanshinone exhibits antioxidant1), antibacterial2), anti-inflammatory3) activities, and acetylcholinesterase inhibition.4) Recent studies have shown that cryptotanshinone has also anti-tumor activity.5,6) (The product is for research purpose only.)
References
- 1)Antioxidative components of tanshen (Salvia miltiorhiza Bung)
- 2)Antibacterial activities of cryptotanshinone and dihydrotanshinone I from a medicinal herb, Salvia miltiorrhiza bunge
- 3)Cryptotanshinone inhibits cyclooxygenase-2 enzyme activity but not its expression
- 4)Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza
- 5)Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells
- 6)Molecular Evidence of Cryptotanshinone for Treatment and Prevention of Human Cancer (a review)
- 7)Simultaneous determination of cryptotanshinone, tanshinone I, and tanshinone IIA in traditional Chinese medicinal preparations containing Radix salvia miltiorrhiza by HPLC
- 8)Simultaneous determination of tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-electrospray ionisation-mass spectrometry
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