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CAS RN: 60628-96-8 | Product Number: B4173
Bifonazole
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Purity: >98.0%(GC)(T)
Synonyms:
- 1-(α,4-Diphenylbenzyl)imidazole
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 1G |
NT$1,720
|
1 | 17 |
| 5G |
NT$3,920
|
5 | ≥40 |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
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* The storage conditions are subject to change without notice.
| Product Number | B4173 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__2__2H__1__8N__2 = 310.40 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 60628-96-8 |
| Reaxys Registry Number | 618427 |
| PubChem Substance ID | 253660017 |
| Merck Index (14) | 1213 |
| MDL Number | MFCD00865567 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 147.0 to 151.0 °C |
Properties (reference)
| Melting Point | 149 °C |
| Solubility (soluble in) | Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | NI3517000 |
Transport Information:
| H.S.code* | 2933.29-000 |
Application
Studies of Antifungal Activity of Bifonazole
Bifonazole is a substituted imidazole antifungal agent, which possesses a broad spectrum of activity against dermatophytes (trichophyton, microsporum, and epidermophyton), yeasts (candida), and malassezia furfur. Bifonazole works by stopping the fungi from producing a substance called ergosterol, which is an essential component of fungal cell membranes.
References
- Structure of Microsomal Cytochrome P450 2B4 Complexed with the Antifungal Drug Bifonazole: insight into P450 conformational plasticity and membrane interaction
- Molecular design of two sterol 14α-demethylase homology models and their interactions with the azole antifungals ketoconazole and bifonazole
- Chiral Azole Derivatives. 4.Enantiomers of Bifonazole and Related Antifungal Agents: Synthesis, Configuration Assignment, and Biological Evaluation
- Antifungal relative inhibition factors: BAY 1-9139, bifonazole, butoconazole, isoconazole, itraconazole (R 51211), oxiconazole, Ro 14-4767/002, sulconazole, terconazole and vibunazole (BAY n-7133) compared
in vitro with nine established antifungal agents - Bifonazole. A review of its antimicrobial activity and therapeutic use in superficial mycoses
- T. E. Lackner, S. P. Clissold, Drugs 1989, 38, 204.
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