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CAS RN: 141430-65-1 | Product Number: A3169
ABT-751
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Purity: >98.0%(HPLC)
Synonyms:
- N-[2-[(4-Hydroxyphenyl)amino]pyridin-3-yl]-4-methoxybenzenesulfonamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
NT$5,712
|
9 | 0 | Contact Us | |
| 50MG |
NT$18,270
|
15 | 1 | Contact Us |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
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* The storage conditions are subject to change without notice.
| Product Number | A3169 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__7N__3O__4S = 371.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 141430-65-1 |
| Reaxys Registry Number | 5455834 |
| PubChem Substance ID | 354335530 |
| MDL Number | MFCD00910291 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 10.70 to 11.90 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 162 °C(dec.) |
GHS
Related Laws:
| RTECS# | DB2734000 |
Transport Information:
| H.S.code* | 2935.90-000 |
Application
ABT-751 (E7010): A Sulfonamide Tubulin Polymerization Inhibitor
ABT-751 (E7010) is a sulfonamide tubulin polymerization inhibitor, which is active against tumor cells. ABT-751 binds to the colchicine site on β-tubulin, and inhibits polymerization of microtubules that leads to a block in the cell cycle at the G2M phase, resulting in cellular apoptosis. (The product is for research purpose only.)
References
- In vivo tumor growth inhibition produced by a novel sulfonamide, E7010, against rodent and human tumors
- Mechanism of action of E7010, an orally active sulfonamide antitumor agent: inhibition of mitosis by binding to the colchicine site of tubulin
- Variations in the colchicine-binding domain provide insight into the structural switch of tubulin
- E7010: investigational anticancer agents targeting the microtubules (a review)
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