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CAS RN: 57-24-9 | Product Number: S0249
Strychnine
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
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| 25G |
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| Product Number | S0249 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__2N__2O__2 = 334.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 57-24-9 |
| Reaxys Registry Number | 52979 |
| PubChem Substance ID | 87575778 |
| SDBS (AIST Spectral DB) | 7596 |
| Merck Index (14) | 8855 |
| MDL Number | MFCD00005941 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -100 to -108 deg(C=0.25, EtOH) |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | -108° (C=0.25,EtOH) |
| Solubility in water | Insoluble |
| Degree of solubility in water | 160 mg/l 25 °C |
| Solubility (soluble in) | Chloroform |
| Solubility (slightly sol. in) | Acetone |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P391 : Collect spillage. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | WL2275000 |
Transport Information:
| UN Number | UN1692 |
| Class | 6.1 |
| Packing Group | I |
| H.S.code* | 2939.79-000 |
Application
Strychnine: An Indole Alkaloid with Antagonistic Activity toward Glycine and Acetylcholine Receptors
Strychnine [S0249] is an indole alkaloid obtained from the seeds and bark of Strychnos nux-vomica, has been used as a rodenticide for more than a century. Glycine is an inhibitory transmitter to motor neurons and interneurons in the spinal cord. Strychnine is a neurotoxin which acts as an antagonist of glycine and acetylcholine receptors, resulting in disinhibition of motor neurons in the spinal cord.1,2) In addition, strychnine has been a target compound for total synthesis since it was first synthesized by the group of R. B. Woodward in 1954.3,4) Strychnine is poorly soluble in water, but its sulfate [S0094], nitrate [S0093] and hydrochloride [S0257] are moderately soluble in water. (The product is for research purpose only.)
References
- 1) The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors
- 2) Inhibitory glycine receptors: an update (a review)
- 3) Synthesis of Strychnine (a review)
- 4) Is There No End to the Total Syntheses of Strychnine? Lessons Learned in Strategy and Tactics in Total Synthesis
Application
Reagents convulsion or paralysis model
References
- Voltage clamp study of cat spinal motoneurons during strychnine-induced seizures
- Prevention of strychnine-induced seizures and death by the N-methylated glycine derivatives betaine, dimethylglycine and sarcosine
- Influence of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on strychnine-induced seizures in mice
- Glycine potentiates strychnine-induced convulsions: role of NMDA receptors
- Strychnine-induced seizures in mice: the role of noradrenaline
- Effects of MK-801 (dizocilpine) and ketamine on strychnine-induced convulsions in rats: comparison with benzodiazepines and standard anticonvulsants
- H. Kubová, P. Mares, Physiol. Res. 1994, 43, 313.
- L-NAME inhibits pentylenetetrazole and strychnine-induced seizures in mice
- Effect of bis(acetato)tetrakis(imidazole) copper(II) in delaying the onset and reducing the mortality rate of strychnine- and thiosemicarbazide- induced convulsions
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