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CAS RN: 176702-70-8 | Product Number: F1301
Fadrozole Hydrochloride Hemihydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile Hydrochloride Hemihydrate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 25MG |
$319.00
|
18 | Contact Us |
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| Product Number | F1301 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__3N__3·HCl·^^1/__2H__2O = 268.75 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic |
| CAS RN | 176702-70-8 |
| Related CAS RN | 102676-31-3 |
| PubChem Substance ID | 468591906 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Precipitation Titration) | min. 98.0 % |
| Melting point | 211.0 to 215.0 °C |
| Water | 3.0 to 4.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 212 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
Transport Information:
| UN Number | UN3439 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2933.99-000 |
Application
Fadrozole Hydrochloride: A Nonsteroidal Aromatase Inhibitor with Potential Antineoplastic Activity
Fadrozole hydrochloride (CGS 16949A) is a nonsteroidal aromatase inhibitor with antineoplastic activity. It has been reported that fadrozole blocks the aromatization of androstenedione and testosterone into estrone and estradiol, respectively. (The product is for research purpose only.)
References
- In vitro and in vivo studies demonstrating potent and selective estrogen inhibition with the nonsteroidal aromatase inhibitor CGS 16949A
- CGS 16949A, a new nonsteroidal aromatase inhibitor: effects on hormone-dependent and -independent tumors in vivo
- Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease
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