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CAS RN: 54573-75-0 | Product Number: D5526
Doxercalciferol
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Purity: >98.0%(HPLC)
Synonyms:
- (5Z,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraene-1,3-diol
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5MG |
$99.00
|
5 | 3 | Contact Us | |
| 25MG |
$357.00
|
10 | 23 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | D5526 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__8H__4__4O__2 = 412.66 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 54573-75-0 |
| Reaxys Registry Number | 4716774 |
| PubChem Substance ID | 468591388 |
| Merck Index (14) | 3436 |
| MDL Number | MFCD00871065 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +46.0 to +50.0 deg(C=0.5,EtOH) |
| Elemental analysis(Carbon) | 79.90 to 83.10 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 140 °C |
| Maximum Absorption Wavelength | 265(EtOH) nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | VS2950000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | I |
| H.S.code* | 2936.29-000 |
Application
Doxercalciferol: A Prodrug of 1α,25-Dihydroxyvitamin D2, an Active Form of Vitamin D2
Doxercalciferol (other name: 1α-hydroxyvitamin D2), a synthetic vitamin D2 analog, was first synthesized from ergosterol [E0018].1) It is a prodrug requiring hepatic metabolism to the active metabolite 1α,25-dihydroxyvitamin D2 (1α, 25-(OH)2D2), a biologically active form of vitamin D2.2) The active vitamin D2 binds the vitamin D receptor (VDR) to result in the selective activation of vitamin D responsive pathway. It has been reported that doxercalciferol reduces parathyroid hormone (PTH) levels by inhibiting PTH synthesis and secretion.3) In clinical, doxercalciferol is used for the treatment of secondary hyperparathyroidism (2HPT) and metabolic bone disease.3,4) (The product is for research purpose only.)
References
- 1) Synthesis of 1α-hydroxyergocalciferol
- 2) 1α,24(S)-dihydroxyvitamin D: a biologically active product of 1α-hydroxyvitamin D made in the human hepatoma, Hep3B
- 3) Vitamin D analogues for secondary hyperparathyroidism
- 4) Doxercalciferol treatment of secondary hyperparathyroidism (a review)
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