Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase (DYRK) Inhibitor

　ID 8 (1) was reported as an indole derivative that can sustain embryonic stem cell self-renewal in long-term culture.¹⁾
　1 inhibits dual-specificity tyrosine phosphorylation-regulated kinase (DYRK).²⁾ 1 supports Wnt-induced human embryonic stem cell proliferation and survival without fibroblast growth factor (FGF) and tumor growth factor-β (TGF-β) supplementation.²⁾

References

• 1) Indole derivatives sustain embryonic stem cell self-renewal in long-term culture
• T. Miyabayashi, M. Yamamoto, A. Sato, S. Sakano, Y. Takahashi, Biosci. Biotechnol. Biochem. 2008, 72, 1242.
• 2) Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion
• K. Hasegawa, S. Yasuda, J.-L. Teo, C. Nguyen, M. McMillan, C.-L. Hsieh, H. Suemori, N. Nakatsuji, M. Yamamoto, T. Miyabayashi, C. Lutzko, M. F. Pera, M. Kahn, Stem Cells Transl. Med. 2012, 1, 18.

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