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Water-soluble Polymers with Biocompatiblility: Poly(2-oxazoline)s
No.180(April 2019)
Poly(2-oxazoline)s are biocompatible and non-immunogenic pseudo-polypeptide-structured polymers. ULTROXA® poly(2-methyl-2-oxazoline) (1), a highly-defined polymer with narrow molar mass distribution, is more hydrophilic than poly(ethylene glycol) (PEG).2a) ULTROXA® poly(2-propyl-2-oxazoline) (2) with a narrow molar mass distribution transitions to a hydrophobic state in water when heated.3a) 1 and 2 have been applied to surface coating,1) drug delivery systems,2) and thermoresponsive material.3)
ULTROXA® is a registered trademark of Ghent University.
References
- 1) a) Poly-2-methyl-2-oxazoline: A peptide-like polymer for protein-repellent surfaces
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b) Polyoxazolines for nonfouling surface coatings — a direct comparison to the gold standard PEG
- 2) a) Polyoxazoline: chemistry, properties, and applications in drug delivery
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b) POxylation as an alternative stealth coating for biomedical applications
- 3) a) Tuning the LCST of poly(2-oxazoline)s by varying composition and molecular weight: alternatives to poly(N-isopropylacrylamide)?
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b) Synthesis of pH- and thermoresponsive poly(2-n-propyl-2-oxazoline) based copolymers
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