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Cyclooxygenase (COX) Inhibitor: Flurbiprofen
No.178(July 2018)
Flurbiprofen (1) functions as a cyclooxygenase (COX) inhibitors and inhibits COX-1 and COX-2 with the IC50s of 0.1 μM and 0.4 μM, respectively.1) 1 exists as a racemic mixture of their enantiomeric form and the S-isomer is a more potent inhibitor of COX isoenzymes than the R-isomer.2,3) 1 is also widely known as a non-steroidal anti-inflammatory drug (NSAID).1) Furthermore, 1 maintains the self-renewal and pluripotency of human embryonic stem cells.4,5)
* Human recombinant COX-1 and COX-2 were used in the reference 1.
This product is for research purpose only.
References
- 1)Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
- 2)Stoichiometric and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents
- 3)Flurprofen and enantiomers in ophthalmic solution tested as inhibitors of prostanoid synthesis in human blood
- 4)High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells
- 5)Histone modification profiling reveals differential signatures associated with human embryonic stem cell self-renewal and differentiation
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