Maximum quantity allowed is 999
请选择数量
p53 Inhibitors
No.161(April 2014)
p53 (Also known as Trp53 in mice, TP53 in humans) is a tumor suppressor protein that is frequently inactivated in tumors.1) It has been revealed that inhibition of p53 can improve the reprogramming efficiency of human and mouse somatic cells.2-7) The protein has been focused on in the research field.8)
Pifithrins are inhibitors of p53. Pifithrin-α is a transcriptional inhibitor of p53 and rapidly converts to the condensation form, cyclic-pifithrin-α (1, also called pifithrin-β).9). Pifithrin-μ (2) was initially identified as a small-molecule inhibitor of the binding of p53 to mitochondria by reducing its affinity to antiapoptic proteins Bcl-xL and Bcl-2.10).
References
- 1)Assessing TP53 status in human tumours to evaluate clinical outcome
- 2)Two supporting factors greatly improve the efficiency of human iPSC generation
- 3)Suppression of Induced pluripotent stem cell generation by the p53-p21 pathway
- 4)The Ink4/Arf locus is a barrier for iPS reprogramming
- 5)Linking the p53 tumour suppressor pathway to somatic cell reprogramming
- 6)Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
- 7)A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
- 8)p53, Stem cells, and reprogramming: tumor suppression beyond guarding the genome
- 9)A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
- 10)Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.