text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

请选择数量

A New Electrophilic Trifluoromethylating Reagent

The design and synthesis of trifluoromethylated compounds have been studied, due to the unique feature of the trifluoromethylated compounds in pharmaceuticals, agrochemicals, and functional materials. Shibata et al. have developed a novel reagent 1 for the trifluoromethylation.1)
Typical procedure: the trifluoromethylation of 1-indanone-2-carboxylic acid methyl ester1)
To a stirred solution of 1-indanone-2-carboxylic acid methyl ester (20 mg, 0.105 mmol) in CH2Cl2 (0.5 mL) DBU (18.8 μL, 0.126 mmol) is added and stirred for 15 min at room temperature. The reagent 1 (51.4 mg, 0.158 mmol) is added and stirred for 15 min at room temperature. The solvent is evaporated, and the residue is purified by column chromatography on silica gel (benzene) to give the trifluoromethylated compound (25.1 mg, Y. 93%) as a pale yellow solid.

References

The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
会话状态
当前会话将在10分钟后超时,并返回主页。请点击按钮继续浏览。分钟后超时,并返回主页。请点击按钮继续浏览。

您的会话已超时,将返回至主页。