用于强效抑制TGF-β信号通路的硫代酰胺

硫代酰胺A 83-01，是TGF-β I型受体超家族的高效抑制剂，可以抑制激活素受体样激酶(Activin-Like Kinase) 4(ALK4)、5 (ALK5)和7 (ALK7)，并特异性地作用于TGF-β信号通路的TGF-β/ Activin A/Nodal分支^1,2)。A 83-01的抑制作用可防止Smad2/3的磷酸化，进而减弱TGF-β介导的生长抑制和上皮间质转化。A 83-01是类器官培养基的常见成分，它与其它利基因子协同使用，可促进干细胞自我分化和自组装成类似于体内天然结构的功能化结构³⁾。

关键词

A3324

A 83-01

相关产品分类页

• 类器官培养
• 丝氨酸/苏氨酸酶抑制剂(其它)

文献

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