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Published TCIMAIL newest issue No.197 | Notice of Discontinuing the Use of Password-Protected Compressed Files | Product Document Searching Made Easy by 2D Code! | TCI Life Science News December 2024 | [Product Highlights] Ready-to-Use Cationic Polymer ... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)

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C-H键活化的杂芳烃三氟甲基化反应

Baran等人报道了zinc(II) bis(trifluoromethanesulfinate) dihydrate (1)可作为一种强大的杂芳烃三氟甲基化试剂^1-3)。相比于其它三氟甲基化试剂，1在空气中显示出更好的化学稳定性且它对杂芳烃具有高反应活性。该反应经历了杂芳烃的一个C-H键的自由基活化。有趣的是，该反应可以在含有一些杂质的水溶液中进行，如细胞裂解液和乌龙茶。因此，1有望应用于生物偶联化学。

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文献

Practical and innate carbon–hydrogen functionalization of heterocycles
- Y. Fujiwara, J. A. Dixon, F. O’Hara, E. D. Funder, D. D. Dixon, R. A. Rodriguez, R. D. Baxter, B. Herle, N. Sach, M. R. Collons, Y. Ichihara, P. S. Baran, Nature 2012, 492, 95.
Preparation and purification of zinc sulfinate reagents for drug discovery
- F. O'Hara, R. D. Baxter, A. G O'Brien, M. R. Collins, J. A. Dixon, Y. Fujiwara, Y. Ishihara, P. S. Baran, Nature Protocols 2013, 8, 1042.
Radical-Based Regioselective C−H Functionalization of ElectronDeficient Heteroarenes: Scope, Tunability, and Predictability
- F. O’Hara, D. G. Blackmond, P. S. Baran, J. Am. Chem. Soc. 2013, 135, 12122.