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CAS RN: 524-12-9 | 产品编码: W0015
Wedelolactone
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| 产品编码 | W0015 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__6H__1__0O__7 = 314.25 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 10MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 524-12-9 |
| Reaxys-RN | 332398 |
| PubChem物质ID | 468593123 |
| MDL编号 | MFCD07778564 |
技术规格
| Appearance | White to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 315 °C |
| 最大吸收波长 | 350 nm (MeOH) |
GHS
相关法规
| RTECS# | DF8078630 |
运输信息
| HS编码* | 2932.20-000 |
应用
Wedelolactone: A Selective and Irreversible Kinase Inhibitor with Broad Range of Biological Activities
Wedelolactone is a natural coumestan originally isolated from herbal plants, including Eclipta alba and in Wedelia calendulacea.1) It has been reported that wedelolactone is a selective and irreversible kinase inhibitor with broad range of biological activities. For example, wedelolactone is a direct inhibitor of IKK complex that can suppress lipopolysaccharide(LPS)-induced caspase-11 expression,2) an antidote for snake venom,3,4) an inhibitor of topoisomerase IIα,5) and an inducer of caspase-dependent apoptosis in cancer cells.6) (The product is for research purpose only.)
References
- 1) Coumestans as the main active principles of the liver drugs Eclipta alba and Wedelia calendulacea
- 2) Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex
- 3) Neutralization of lethal and myotoxic activities of South American rattlesnake venom by extracts and constituents of the plant Eclipta prostrata (Asteraceae)
- 4) Ability of wedelolactone, heparin, and para-bromophenacyl bromide to antagonize the myotoxic effects of two crotaline venoms and their PLA2 myotoxins
- 5) Inhibition of topoisomerase IIα: Novel function of wedelolactone
- 6) Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt
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