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CAS RN: 745833-23-2 | 产品编码: V0147
VX-702
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纯度/分析方法: >98.0%(HPLC)
别名：
- VX-702
- 6-[(氨基羰基)(2,6-二氟苯基)氨基]-2-(2,4-二氟苯基)-3-吡啶甲酰胺
- 2-(2,4-二氟苯基)-6-(1-[2,6-二氟苯基)脲基]烟酰胺
- 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide
- 2-(2,4-Difluorophenyl)-6-(1-[2,6-difluorophenyl)ureido]nicotinamide
产品文档：
| 产品编码 | V0147 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__9H__1__2F__4N__4O__2 = 404.32 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 745833-23-2 |
| Reaxys-RN | 14288211 |
| PubChem物质ID | 354335240 |
| MDL编号 | MFCD11616590 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 13.00 to 14.50 % |
物性（参考值）
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2933.39-000 |
应用
VX-702: A p38 Mitogen-Activated Protein Kinase (MAPK) Inhibitor
VX-702 is a p38 mitogen-activated protein kinase (MAPK) inhibitor. The p38 MAPK belongs to a family of serine-threonine kinases, which are activated by dual phosphorylation of threonine and tyrosine residues.
References
- Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation
- p38 MAP kinase inhibitors: Many are made, but few are chosen
- Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome
参考文献
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