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CAS RN: 2068-78-2 | 产品编码: V0129
Vincristine Sulfate
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| 产品编码 | V0129 |
| 纯度/分析方法 | >95.0%(HPLC) |
| 分子式/分子量 | C__4__6H__5__6N__4O__1__0·H__2SO__4 = 923.04 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿),加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 2068-78-2 |
| Reaxys-RN | 8047628 |
| PubChem物质ID | 468593101 |
| Merck Index (14) | 9986 |
| MDL编号 | MFCD08706469 |
技术规格
| Appearance | White to Light yellow powder to crystaline |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation [a]20/D | +24.0 to +32.0 deg(C=2, H2O，calcd.on dried substance) |
| Drying loss | max. 15.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 300 °C |
| 最大吸收波长 | 293(MeOH) nm |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H300 : Fatal if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. H341 : Suspected of causing genetic defects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | OH6340000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | II |
| HS编码* | 2939.79-000 |
应用
Vincristine Sulfate: An Antitumor Vinca Alkaloid
Vincristine Sulfate is an antitumor vinca alkaloid obtained from a common flowering herb, the periwinkle plant (Vinca rosea Linn). The exact mechanism of action has not been determined, but vincristine sulfate has been related to the inhibition of microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. Vincristine has been reported to have neurotoxic side effects. However, the liposome encapsulation of vincristine enhances the efficacy of the vincristine antitumor activity while simultaneously decreasing the neurotoxicity associated with it. (The product is for research purpose only.)
References
- Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle (a review)
- The effect of antimicrotubule agents on signal transduction pathways of apoptosis. A review
- Marqibo® (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine
- Vincristine sulfate. (Supplement) (A review with 80 references description, physical properties, isolation, synthesis, pharmacokinetics, preparation and preservation, uses and methods of analysis.)
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