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CAS RN: 152-11-4 | 产品编码: V0118
Verapamil Hydrochloride
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 143.0 to 147.0 °C |
物性（参考值）
| 熔点 | 145 °C |
| 水溶性 | 微溶 |
| 溶解性（可溶于） | 乙醇, 甲醇 |
| 溶解性（不溶于） | 乙醚 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相关法规
| RTECS# | YV8320000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2926.90-000 |
应用
Lentivirus vector transduction enhancer
Verapamil increases transduction by VSV-G–pseudotyped lentiviral vectors.1)
References
- 1) ABC transporter inhibitors that are substrates enhance lentiviral vector transduction into primitive hematopoietic progenitor cells
应用
Verapamil Hydrochloride: The First Calcium-Channel Antagonist (Blocker)
Calcium channel antagonists (blockers) are chemicals that disrupt the movement of calcium ion (Ca2+) through calcium channels in the cell membrane. Verapamil hydrochloride, which is the first calcium channel antagonist, prolongs atrioventricular (A-V) conduction (A-H interval) in a dose-dependent manner. It is an effective antianginal agent when directly compared with a β-blocker, and is more effective in reducing myocardial ischemia compared with amlodipine monotherapy. Recently, various formulations have been reported to achieve efficient drug incorporation with a satisfactory in vitro drug release rate. (The product is for research purpose only.)
References
- Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem
- Verapamil (a review of its pharmacological properties and therapeutic use in coronary artery disease)
- The effect of the drug/polymer ratio on the properties of the verapamil HCl loaded microspheres
- Controlled release of verapamil hydrochloride from waxy microparticles prepared by spray congealing
- Swelling studies and in vitro release of verapamil from calcium alginate and calcium alginate-chitosan beads
参考文献
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