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CAS RN: 99300-78-4 | 产品编码: V0110
Venlafaxine Hydrochloride
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| 产品编码 | V0110 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__7H__2__7NO__2·HCl = 313.87 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 应避免的情况 | 光 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 99300-78-4 |
| 相关CAS RN | 93413-69-5 |
| Reaxys-RN | 4240401 |
| PubChem物质ID | 125307750 |
| SDBS (AIST Spectral DB) | 52922 |
| Merck Index (14) | 9946 |
| MDL编号 | MFCD03658865 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
物性（参考值）
| 熔点 | 217 °C |
| 溶解性（可溶于） | 甲醇 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H302 : Harmful if swallowed. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | QV8872760 |
运输信息
| HS编码* | 2922.50-000 |
应用
Venlafaxine Hydrochloride: A Serotonin/Norepinephrine Reuptake Inhibitor (SNRI)
Venlafaxine hydrochloride belongs to a serotonin [S0370] /norepinephrine [A0906] reuptake inhibitors (SNRIs). Studies have shown that venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV) [D5598], are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine [A0305] reuptake. Venlafaxine and ODV have no significant affinity for muscarinic cholinergic, H1-histaminergic, or α1-adrenergic receptors in vitro. For your reference, duloxetine hydrochloride [D4223] and milnacipran hydrochloride [M2133] also belong to SNRIs. (The product is for research purpose only.)
References
- Biochemical, neurophysiological, and behavioral effects of Wy-45,233 and other identified metabolites of the antidepressant venlafaxine
- Venlafaxine oxidation in vitro is catalyzed by CYP2D6
- Venlafaxine: a review of its pharmacology and therapeutic potential in depression (a review)
- Comparative Affinity of Duloxetine and Venlafaxine for Serotonin and Norepinephrine Transporters in vitro and in vivo, Human Serotonin Receptor Subtypes, and Other Neuronal Receptors
- Use of vancomycin silica stationary phase in packed capillary electrochromatography. II. Enantiomer separation of venlafaxine and O-desmethylvenlafaxine in human plasma
- Development and validation of stability indicating method for the quantitative determination of venlafaxine hydrochloride in extended release formulation using high performance liquid chromatography
参考文献
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