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CAS RN: 293754-55-9 | 产品编码: T4241
产品编码 | T4241 |
纯度/分析方法 | >98.0%(HPLC)(qNMR) |
分子式/分子量 | C__1__7H__1__2F__9NO__3S = 481.33 |
外观与形状(20°C) | 固体 |
储存温度 | 冷冻 (-20°C) |
储存在惰性气体下 | 存放于惰性气体之中 |
应避免的情况 | 空气,加热 |
CAS RN | 293754-55-9 |
Reaxys-RN | 10385659 |
技术规格
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(qNMR) | min. 98.0 % |
Melting point | 118.0 to 122.0 °C |
NMR | confirm to structure |
物性(参考值)
熔点 | 120 °C |
GHS
相关法规
RTECS# | DB3192000 |
运输信息
HS编码* | 2935.90-000 |
应用
T 0901317: An Orally Active and Highly Selective LXR Agonist
Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid and glucose homeostasis. LXR agonists have been reported to be effective in the treatment of mouse models of atherosclerosis, diabetes and Alzheimer's disease. T 0901317 is an orally active and highly selective LXR agonist that induces apoptosis in cancer cells and inhibits the development of atherosclerosis in mice. (The product is for research use only.)
References
- Role of LXRs in control of lipogenesis
- T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice
- The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease
- Modulation of liver X receptor signaling as novel therapy for prostate cancer (a review)
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