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CAS RN: 62996-74-1 | 产品编码: T4000
Staurosporine
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纯度/分析方法: >98.0%(HPLC)
别名：
- 星孢菌素
- (5S,6R,7R,9S)-6-甲氧基-5-甲基-7-甲氨基-6,7,8,9,15,16-六氢-5H,14H-17-氧杂-4b,9a,15-三氮杂-5,9-甲桥二苯并[b,h]环壬并[jkl]环戊并[e]-不对称引达省-14-酮
- (5S,6R,7R,9S)-6-Methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14-one
产品文档：
| 产品编码 | T4000 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__8H__2__6N__4O__3 = 466.54 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 10MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 62996-74-1 |
| Reaxys-RN | 6674025 |
| PubChem物质ID | 468593064 |
| MDL编号 | MFCD18252446 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | +71.0 to +75.0 deg(C=0.1, ﾒﾀﾉｰﾙ) |
| NMR | confirm to structure |
物性（参考值）
GHS
| 危险性说明 | H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相关法规
| RTECS# | KC6550000 |
运输信息
| HS编码* | 2941.90-000 |
应用
Staurosporine: A Potent Inhibitor of Protein Kinase
Staurosporine (AM-2282) is an indolocarbazole antibiotic originally isolated from the bacterium Streptomyces staurosporeus by Omura et al. in 1977.1) It has been reported that staurosporine and display strong inhibitory effect against a variety of kinases including protein kinase C (PKC), and a number of biological properties such as antifungal, antibacterial, and apoptosis-inducing activities1,2). Staurosporine also inhibits wild-type LRRK2 (leucine-rich repeat kinase 2), which is a large protein (2527 amino acids) with serine-threonine (Ser/Thr) protein kinase activity and autophosphorylation activity.3) Nevertheless, staurosporine is poorly selective against other protein kinases. To obtain specific PKC inhibitors, a number of its analogues has been developed.4,5) (The product is for research purpose only.)
References
- 1) Staurosporine, a Potentially Important Gift from a Microorganism (a review)
- 2) Induction of a common pathway of apoptosis by staurosporine
- 3) Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2
- 4) Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine (a review)
- 5) Protein kinase inhibition of clinically important staurosporine analogues (a review)
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