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CAS RN: 321-64-2 | 产品编码: T3994
Tacrine
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技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 181.0 to 185.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 183 °C |
| 最大吸收波长 | 325 nm (EtOH) |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | AR9532100 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2933.99-000 |
应用
Mitochondria research
References
- Tacrine Inhibits Topoisomerases and DNA Synthesis to Cause Mitochondrial DNA Depletion and Apoptosis in Mouse Liver
- Uncoupling of Rat and Human Mitochondria: A Possible Explanation for Tacrine-Induced Liver Dysfunction
应用
Tacrine: A Reversible Cholinesterase Inhibitor
Tacrine is a reversible cholinesterase inhibitor, and the first approved agent for the treatment of Alzheimer's disease.1) The mechanism of action of tacrine is thought to inhibit the metabolism of acetylcholine and therefore extending its activity and raising levels in the cerebral cortex.2,3) However, since tacrine shows various side effects and toxicity, the development of the next generation inhibitors such as donepezil [D4099 (HCl salt)] is underway.3,4) (The product is for research purpose only.)
References
- 1) Tacrine
- 2) Tacrine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in Alzheimer's disease
- 3) A review on cholinesterase inhibitors for Alzheimer's disease
- 4) A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease
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