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CAS RN: 134308-13-7 | 产品编码: T3856
Tolcapone
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| 产品编码 | T3856 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__4H__1__1NO__5 = 273.24 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 200MG-Glass Bottle with Plastic Insert （查看图片）, 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 134308-13-7 |
| Reaxys-RN | 8151577 |
| PubChem物质ID | 468592985 |
| Merck Index (14) | 9508 |
| MDL编号 | MFCD00866569 |
技术规格
| Appearance | White to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 142.0 to 146.0 °C |
物性（参考值）
| 熔点 | 145 °C |
GHS
相关法规
| RTECS# | PC4952500 |
运输信息
| HS编码* | 2914.79-000 |
应用
Tolcapone: A Selective and Reversible Inhibitor of Catechol-O-methyltransferase (COMT)
Tolcapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT) which is one of several enzymes that degrade catecholamines (such as L-DOPA [D0600], dopamine [A0305], L-epinephrine [A0173], and norepinephrine [A0906]). COMT catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure including catecholamines. Tolcapone crosses the blood-brain barrier and can inhibit both peripheral and central COMT activity. Therefore, it has been suggested that tolcapone prolong the biological half-life of L-DOPA and the therapeutic effect of L-DOPA for Parkinson's disease patients. (The product is for research purpose only.)
References
- Effects of tolcapone, a novel catechol-O-methyltransferase inhibitor, on striatal metabolism of L-DOPA and dopamine in rats
- Catechol-O-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex
- Catechol-O-methyltransferase and its inhibitors in Parkinson's disease (a review)
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