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CAS RN: 148741-30-4 | 产品编码: T3696
Tyrphostin AG 879
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技术规格
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 230.0 to 234.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 232 °C |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
相关法规
| RTECS# | UD1980000 |
运输信息
| HS编码* | 2930.90-900 |
应用
Ttyrphostin AG 879: A RTK Inhibitor
RTKs (Receptor tyrosine kinases), transmembrane glycoproteins present on cell surface, are important molecules in biological phenomenon to control basic cell activities such as proliferation, differentiation, survival and death. It has been reported that tyrphostin AG 879 inhibits RTKs with anti-proliferative activities against cancer cells and viruses. (The product is for research purpose only.)
References
- The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor
- Synergy of Epidermal Growth Factor Receptor Kinase Inhibitor AG1478 and ErbB2 Kinase Inhibitor AG879 in Human Colon Carcinoma Cells Is Associated with Induction of Apoptosis
- Receptor tyrosine kinase inhibitors block multiple steps of influenza A virus replication
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