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CAS RN: 150915-40-5 | 产品编码: T3640
Tirofiban Hydrochloride Monohydrate
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| 产品编码 | T3640 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__2H__3__6N__2O__5S·HCl·H__2O = 495.08 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 250MG-Glass Bottle with Plastic Insert （查看图片）, 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 150915-40-5 |
| 相关CAS RN | 144494-65-5&142373-60-2 |
| Reaxys-RN | 14636978 |
| PubChem物质ID | 354335596 |
| Merck Index (14) | 9464 |
| MDL编号 | MFCD07368623 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 5.00 to 6.00 % |
| Specific rotation [a]20/D | -12.0 to -16.0 deg(C=1, MeOH) |
| Water | 3.1 to 4.1 % |
物性（参考值）
| 熔点 | 132 °C |
| 比旋光度 [α]D | -14° (C=1,MeOH) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2935.90-000 |
应用
Tirofiban Hydrochloride: A Nonpeptide Glycoprotein IIb/IIIa Receptor Antagonist
Tirofiban hydrochloride is a reversible antagonist of fibrinogen binding to the platelet glycoprotein (GP) IIb/IIIa receptor, the major platelet surface receptor. GP IIb/IIIa plays a major role in the regulation of platelet adhesion and aggregation during hemostasis, and the GP IIb/IIIa receptor has been identified as the pivotal mediator of platelet aggregation. Therefore, tirofiban hydrochloride specifically inhibits fibrinogen-dependent platelet aggregation and prolongs bleeding times. (The product is for research purpose only.)
References
- Tirofiban: an investigational platelet glycoprotein IIb/IIIa receptor antagonist (a review)
- Glycoprotein IIb/IIIa integrin blockade
- In vitro and in vivo studies on the metabolism of tirofiban
- Integrin αIIbβ3: From Discovery to Efficacious Therapeutic Target
- Determination of Tirofiban in human serum by liquid chromatography-tandem mass spectrometry
- Validated spectrofluorimetric methods for the determination of apixaban and tirofiban hydrochloride in pharmaceutical formulations
参考文献
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