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CAS RN: 251992-66-2 | 产品编码: T3498
4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide
![Thumbnail of 4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide](/medias/T3498.jpg?context=bWFzdGVyfHJvb3R8MTQ1MzF8aW1hZ2UvanBlZ3xhR0kwTDJnNE1TODRPVE0zTURneU5URTVOVGd5TDFRek5EazRMbXB3Wnd8YmY0Zjc1ZWQ1MTVjMTAwZDg2MDhkYjljNGE5ZmExMjRmNTFkZTQzNDQ5NjAyYzFkODJjN2ZkNzc5NWMzMmQ2OA "4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide")
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技术规格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Elemental analysis(Nitrogen) | 8.80 to 9.80 % |
| Melting point | 198.0 to 202.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 200 °C |
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
An Inhibitor of the Induced Expression of Intercellular Adhesion Molecule-1 (ICAM-1) and E-Selection
It is reported that this compound is a potent and selective inhibitor of the induced expression of E-selection and intercellular adhesion molecule-1 (ICAM-1) relative to vascular cell adhesion molecule-1 (VCAM-1). For your information, E-selectin, ICAM-1, and VCAM-1 play a role in cell adhesion to the vascular endothelium. E-selectin is expressed on inflamed vascular endothelial cells in response to treatment with inflammatory cytokines.
References
- Discovery of Inhibitors of Cell Adhesion Molecule Expression in Human Endothelial Cells. 1. Selective Inhibition of ICAM-1 and E-Selectin Expression
- Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides
PubMed Literature
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