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CAS RN: 163451-81-8 | 产品编码: T3287
Teriflunomide
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| 产品编码 | T3287 |
| 纯度/分析方法 | >98.0%(GC) |
| 分子式/分子量 | C__1__2H__9F__3N__2O__2 = 270.21 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 163451-81-8 |
| Reaxys-RN | 6655982 |
| PubChem物质ID | 253661385 |
| Merck Index (14) | 9165 |
| MDL编号 | MFCD00910058 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 227.0 to 231.0 °C |
物性（参考值）
| 熔点 | 229 °C |
| 最大吸收波长 | 203 nm (MeOH) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
运输信息
| HS编码* | 2926.90-000 |
应用
Teriflunomide: An Immunomodulatory Compound
Teriflunomide (A77 1726), the active metabolite of leflunomide [L0250], is an immunomodulatory compound. Teriflunomide has two activites: inhibition of pyrimidine nucleotide synthesis and interference with tyrosine phosphorylation. More specifically, it inhibits the enzymic activity of dihydroorotate dehydrogenase (DHO-DHase) which catalyzes the fourth step in the biosynthesis of pyrimidine, and tyrosine kinases which transfer a phosphate group from ATP to a protein in a cell. Teriflunomide reduces the proliferation of T and B immune cells that are active in multiple sclerosis (MS). For your reference, [C3217] is a synthetic intermediate. (The product is for research purpose only.)
References
- Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound
- The Immunosuppressive Metabolite of Leflunomide Is a Potent Inhibitor of Human Dihydroorotate Dehydrogenase
- The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms
- Teriflunomide and Its Mechanism of Action in Multiple Sclerosis (a review)
- Measurement of the active leflunomide metabolite (A77 1726) by reverse-phase high-performance liquid chromatography
- Quantitation of total and free teriflunomide (A77 1726) in human plasma by LC-MS/MS
参考文献
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