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CAS RN: 89778-27-8 | 产品编码: T2832
Toremifene Citrate
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 枸橼酸托瑞米芬
- (Z)-4-氯-1-(4-二甲基氨基乙氧基苯基)-1,2-二苯基-1-丁烯柠檬酸盐
- (Z)-2-[4-(4-氯-1,2-二苯基-1-丁烯基)苯氧基]-N,N-二甲基乙胺柠檬酸盐
- (Z)-4-Chloro-1-(4-dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene Citrate
- (Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine Citrate
产品文档：
| 产品编码 | T2832 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__6H__2__8ClNO·C__6H__8O__7 = 598.09 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 89778-27-8 |
| 相关CAS RN | 89778-26-7 |
| Reaxys-RN | 8181005 |
| PubChem物质ID | 160871014 |
| Merck Index (14) | 9550 |
| MDL编号 | MFCD01729016 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
物性（参考值）
| 熔点 | 162 °C(dec.) |
| 溶解性（可溶于） | 甲醇 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P273 : Avoid release to the environment. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相关法规
运输信息
| HS编码* | 2921.49-000 |
应用
Biofilm research
Reference
- Repurposing Toremifene for Treatment of Oral Bacterial Infections
应用
Toremifene Citrate: A Selective Estrogen Receptor Modulator (SERM)
Toremifene citrate is a widely used nonsteroidal anti-estrogen agent for the treatment of hormone-dependent breast cancer. Toremifene is metabolized by cytochrome P450 (CYP450) enzymes into active metabolites N-desmethyltoremifene which has anti-estrogen activity as well. They act as an estrogen receptor antagonist in breast tissue. Tamoxifen is commonly referred to as a selective estrogen receptor modulator (SERM), since it behaves as an estrogen receptor agonist in other tissues. (The product is for research purpose only.)
References
- Toremifene prevents prostate cancer in the transgenic adenocarcinoma of mouse prostate model
- Effects of the antiestrogens tamoxifen, toremifene, and ICI 182,780 on endometrial cancer growth
- Effects of chronic administration of tamoxifen and toremifene on DNA adducts in rat liver, kidney, and uterus
- Pharmacokinetics of selective estrogen receptor modulators (a review)
- Selective estrogen receptor modulators (SERMs): Mechanisms of anticarcinogenesis and drug resistance (a review)
应用
Studies on Materials for Controlled Release of Toremifene Citrate
References
- Silica xerogel as an implantable carrier for controlled drug delivery-evaluation of drug distribution and tissue effects after implantation
- Silica xerogel carrier material for controlled release of toremifene citrate
参考文献
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