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CAS RN: 50-35-1 | 产品编码: T2524
(±)-Thalidomide
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| 产品编码 | T2524 |
| 纯度/分析方法 | >98.0%(HPLC)(N) |
| 分子式/分子量 | C__1__3H__1__0N__2O__4 = 258.23 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 50-35-1 |
| Reaxys-RN | 30233 |
| PubChem物质ID | 253662357 |
| Merck Index (14) | 9255 |
| MDL编号 | MFCD00153873 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
物性（参考值）
| 熔点 | 276 °C |
| 最大吸收波长 | 300 nm |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 60 mg/l 25 °C |
| 溶解性（不溶于） | 乙醚, 苯, 氯仿 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. H312 : Harmful in contact with skin. H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P405 : Store locked up. |
相关法规
| RTECS# | TI4375000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2925.19-000 |
应用
Thalidomide: An Inhibitor of Angiogenesis
Thalidomide was originally used to treat morning sickness, but was banned as a human teratogen in the 1960s. In the 1990s, thalidomide has been discovered to have anti-inflammatory and anti-angiogenic properties, and is identified as an effective treatment for multiple myeloma. A recently approved amino analogue of thalidomide is pomalidomide [P2074]. (The product is for research purpose only.)
References
- Thalidomide selectively inhibits tumor necrosis factor α (TNF-α) production by stimulated human monocytes
- Thalidomide is an inhibitor of angiogenesis
- Antitumor activity of thalidomide in refractory multiple myeloma
- Timeline: The evolution of thalidomide and its IMiD derivatives as anticancer agents (a review)
- Multiple Myeloma (a review)
参考文献
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