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CAS RN: 3902-71-4 | 产品编码: T2267
Trioxsalen
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技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 232.0 to 236.0 °C |
物性（参考值）
| 熔点 | 234 °C |
| 水溶性 | 不溶 |
| 溶解性（微溶于） | 醇, 氯仿 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H314 : Causes severe skin burns and eye damage. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dusts or mists. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 : Wash contaminated clothing before reuse. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P405 : Store locked up. |
相关法规
| RTECS# | LV1576000 |
运输信息
| UN编号 | UN1759 |
| 类别 | 8 |
| 包装类别 | III |
| HS编码* | 2932.99-000 |
应用
4,5',8-Trimethylpsoralen: A Photosensitizer in Combination with UV-A irradiation, called PUVA
5-Methoxypsoralen (5-MOP) [B2840], 8-methoxypsoralen (8-MOP) [X0009] and 4,5',8-trimethylpsoralen are naturally occurring linear psoralens (furocoumarins). They have been successfully used as photosensitizers in combination with UV-A irradiation which is called the psoralen-based PUVA (psoralen + UV-A) to manage dermatological diseases, such as psoriasis, vitiligo and cancer. Reportedly, the most important mechanism implies the [2 + 2] cycloaddition photoreaction of psoralen and a DNA pyrimidine nucleobase. The formation of psoralen-pyrimidine adducts prevents the division of the injured cells. In another photoreaction, the activated psoralen can transfer energy to molecular oxygen to generate reactive radicals or excited singlet oxygen which becomes prone to damage the membrane of the harmed cell. Furthermore, 4,5',8-trimethylpsoralen-conjugated oligonucleotides have been used in the study of photo-cross-linking with target oligonucleotides. (The product is for research purpose only.)
References
- The evolution of photochemotherapy with psoralens and UVA (PUVA): 2000 BC to 1992 AD (a review)
- The psoralen-DNA photoreaction. Characterization of the monoaddition products from 8-methoxypsoralen and 4,5',8-trimethylpsoralen
- Psoralen-crosslinking of DNA as a probe for the structure of active nucleolar chromatin
- Psoralen covalently linked to oligodeoxyribonucleotides: synthesis, sequence specific recognition of DNA and photo-cross-linking to pyrimidine residues of DNA
- Synthesis of Oligonucleotides Containing 4,5',8-Trimethylpsoralen at the 2'-O Position and Their Cross-Linking Properties with RNAs (a review)
- Analytical profiles of drug substances. Trioxsalen (A review on trioxsalen, its description, isolation, synthesis, physical properties, methods of analysis, metabolites, and photoreaction between trioxsalen and nucleic acids.)
参考文献
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