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CAS RN: 304909-07-7 | 产品编码: S0971
SANT-1
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| 产品编码 | S0971 |
| 纯度/分析方法 | >95.0%(GC) |
| 分子式/分子量 | C__2__3H__2__7N__5 = 373.50 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 光,湿气 (分解),加热 |
| CAS RN | 304909-07-7 |
| Reaxys-RN | 15638831 |
| MDL编号 | MFCD01827306 |
技术规格
| Appearance | White to Orange to Green powder to crystal |
| Purity(GC) | min. 95.0 % |
| Melting point | 108.0 to 112.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 110 °C |
GHS
相关法规
运输信息
| HS编码* | 2933.59-000 |
应用
SANT-1: A Smoothened (SMO) Antagonist
Smoothened (SMO) is a member of the Frizzled family of seven transmembrane proteins (GPCRs). SMO mediates signal transduction in the hedgehog pathway, which is implicated in normal development and carcinogenesis. It has been reported that SANT-1 is a SMO antagonist which has anti-tumour effect through its ability to bind to smoothened protein.
References
- Evidence for allosteric interactions of antagonist binding to the Smoothened receptor
- Guggulsterone sensitizes glioblastoma cells to Sonic hedgehog inhibitor SANT-1 induced apoptosis in a Ras/NFκB dependent manner
- I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs (a review)
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