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CAS RN: 6533-68-2 | 产品编码: S0021
Scopolamine Hydrobromide Trihydrate
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 数量 |
|---|---|---|---|---|
| 1G |
S$151.50
|
19 | ≥60 |
|
| 10G |
S$739.50
|
5 | ≥40 |
|
| 产品编码 | S0021 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__7H__2__1NO__4·HBr·3H__2O = 438.32 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 应避免的情况 | 光 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 6533-68-2 |
| 相关CAS RN | 114-49-8&51-34-3 |
| Reaxys-RN | 6100669 |
| PubChem物质ID | 87575651 |
| Merck Index (14) | 8406 |
| MDL编号 | MFCD00012647 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(after drying) |
| Specific rotation [a]20/D | -24.0 to -27.0 deg(C=5, H2O)(after drying) |
| Solubility in Water | almost transparency |
| Drying loss | max. 13.0 % |
物性（参考值）
| 熔点 | 195 °C |
| 比旋光度 [α]D | -25.5° (C=5,H2O) |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | YM4550000 |
运输信息
| UN编号 | UN1544 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2939.79-000 |
应用
Scopolamine Hydrobromide: A Belladonna Alkaloid with Anticholinergic Activity
Scopolamine salts ([S0021][ S0230] and [S0231]) and N-oxide [S0229], belladonna alkaloids, are anticholinergic agents. Their free base, scopolamine competitively inhibits muscarinic receptors of the parasympathetic nervous system for acetylcholine and act as a nonselective muscarinic antagonist, producing peripheral anti-muscarinic, central sedative and antiemetic effects. The parasympatholytic scopolamine, structurally very similar to atropine [A0754] as well, is used in conditions requiring decreased parasympathetic activity. Therefore, scopolamine can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, and increase heart rate et al. (The product is for research purpose only.)
References
- The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies (a review)
- Analytical profile of scopolamine hydrobromide (a review on description, synthesis, physical properties, analytical stability and storage, pharmacology, and pharmacokinetics)
- HPLC determination of atropine sulfate and scopolamine hydrobromide in pharmaceuticals
- Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry
应用
Reagent for experimental amnesia (Alzheimer's disease) model
References
- Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat
- Scopolamine as an antidepressant: a systematic review
- Antidepressant effects of the muscarinic cholinergic receptor antagonist scopolamine: a review
参考文献
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