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CAS RN: 224452-66-8 | 产品编码: R0282
Retapamulin
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纯度/分析方法: >98.0%(HPLC)(qNMR)
别名：
- 瑞他莫林
- 2-[[(1R,3s,5S)-8-甲基-8-氮杂双环[3.2.1]辛-3-基]硫代]乙酸(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-羟基-4,7,9,12-四甲基-3-氧代-7-乙烯基十氢-4,9a-丙桥环戊并[8]轮烯-5-基酯
- SB-275833
- (3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-[[(1R,3s,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl]thio]acetate
产品文档：
| 产品编码 | R0282 |
| 纯度/分析方法 | >98.0%(HPLC)(qNMR) |
| 分子式/分子量 | C__3__0H__4__7NO__4S = 517.77 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 224452-66-8 |
| Reaxys-RN | 10626337 |
| MDL编号 | MFCD11045316 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
GHS
| 危险性说明 | H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相关法规
| RTECS# | AI8976800 |
运输信息
| HS编码* | 2941.90-000 |
应用
Retapamulin: A Semi-Synthetic Derivative of the Naturally Occurring Antibiotic Pleuromutilin
Retapamulin (SB-275833) is a semi-synthetic derivative of the naturally occurring pleuromutilin produced by Pleurotus mutilus, an edible mushroom. Retapamulin inhibits bacterial protein biosynthesis in Staphylococcus aureus organisms by inhibiting translation and formation of the 50S ribosomal subunit in cells. (The product is for research use only.)
References
- Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant Gram-positive cocci
- Retapamulin Inhibition of Translation and 50S Ribosomal Subunit Formation in Staphylococcus aureus Cells
- Retapamulin: a review of its use in the management of impetigo and other uncomplicated superficial skin infections
- Efficient Antibacterial Agents: A Review of the Synthesis, Biological Evaluation and Mechanism of Pleuromutilin Derivatives (a review)
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