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CAS RN: 123441-03-2 | 产品编码: R0250
Rivastigmine
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技术规格
| Appearance | Colorless to Light yellow clear liquid |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | -31.0 to -35.0deg (C=1, ethanol) |
| NMR | confirm to structure |
物性（参考值）
| 沸点 | 135 °C/0.26 mmHg |
| 闪点 | 145.0 °C |
| 比重 | 1.03 |
| 水溶性 | 微溶 |
| 溶解性（可与之混溶） | 甲醇, 乙醇 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | FA9546000 |
运输信息
| UN编号 | UN2810 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2924.29-000 |
应用
Rivastigmine: A Dual Inhibitor of Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE)
Rivastigmine is an inhibitor of two cholinesterase enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Rivastigmine activates central cholinergic nervous system by increasing the concentration of acetylcholine (ACh) in brain through reversible inhibition of its hydrolysis by AChE and BuChE. For comparison, another cholinesterase inhibitor, donepezil hydrochloride [D4099] shows high selectivity for AChE over BuChE. In clinical, its tartrate [R0093] is used for the treatment of Alzheimer’s disease. (The product is for research purpose only.)
References
- Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro
- Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine
- Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors
- A review of rivastigmine: a reversible cholinesterase inhibitor
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