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CAS RN: 87333-19-5 | 产品编码: R0219
Ramipril
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 雷米普利
- (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(乙氧羰基)-3-苯丙基]氨基]-1-氧代丙基]八氢环戊并[b]吡咯-2-羧酸
- (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic Acid
产品文档：
| 产品编码 | R0219 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__3H__3__2N__2O__5 = 416.52 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 87333-19-5 |
| Reaxys-RN | 4214464 |
| PubChem物质ID | 468592790 |
| Merck Index (14) | 8103 |
| MDL编号 | MFCD00865775 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 106.0 to 110.0 °C |
| Specific rotation [a]20/D | +35.0 to +41.0 deg(C=1, 0.1N HCl in EtOH) |
物性（参考值）
| 熔点 | 109 °C |
| 比旋光度 [α]D | 40° (C=1,0.1 NHCl in EtOH) |
| 溶解性（可溶于） | 甲醇 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H360 : May damage fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | GY5879600 |
运输信息
| HS编码* | 2933.99-000 |
应用
Ramipril: An Angiotensin-Converting Enzyme (ACE) Inhibitor
Ramipril (Hoe 498) is an angiotensin-converting enzyme (ACE) inhibitor. Ramipril is a prodrug which is rapidly hydrolyzed to the active metabolite ramiprilat by hepatic cleavage of the ester group. ACE, a peptidyl dipeptidase, circulates in the plasma and is located on the surface of endothelial cells. ACE is catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Thereby, ACE inhibitors reduce peripheral vascular resistance and blood pressure. For your reference, we also have a related synthetic intermediate [B5344] of ramipril. (The product is for research purpose only.)
References
- Ramipril. A review of its pharmacological properties and therapeutic efficacy in cardiovascular disorders
- Ramipril: a review of its use in the prevention of cardiovascular outcomes
- Analysis of ACE inhibitors in pharmaceutical dosage forms by derivative UV spectroscopy and liquid chromatography (HPLC)
- A stability-indicating LC method for the simultaneous determination of ramipril and hydrochlorothiazide in dosage forms
- Simultaneous RP-LC determination of losartan potassium, ramipril, and hydrochlorothiazide in pharmaceutical preparations
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