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CAS RN: 82640-04-8 | 产品编码: R0109
Raloxifene Hydrochloride
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| 产品编码 | R0109 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__8H__2__7NO__4S·HCl = 510.05 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 82640-04-8 |
| 相关CAS RN | 84449-90-1 |
| Reaxys-RN | 6036780 |
| PubChem物质ID | 172089090 |
| Merck Index (14) | 8098 |
| MDL编号 | MFCD01938233 |
技术规格
| Appearance | Light yellow to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
物性（参考值）
| 熔点 | 263 °C |
| 最大吸收波长 | 286 nm |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | PC4956925 |
运输信息
| HS编码* | 2934.99-000 |
应用
Raloxifene Hydrochloride: Selective Estrogen Receptor Modulator (SERM)
Raloxifene hydrochloride is a nonsteroidal estrogen agonist/antagonist, commonly referred to as a selective estrogen receptor modulator (SERM). Raloxifene is a therapeutic agent for postmenopausal osteoporosis, and also is indicated for the reduction in risk of invasive breast cancer in postmenopausal women. The biological actions are mediated through binding to estrogen receptors in the cell nucleus. This binding results in activation of estrogenic pathways in bone (agonism) and blockade of estrogenic pathways in breast and uterus (antagonism). (The product is for research purpose only.)
References
- Molecular determinants for the tissue specificity of SERMs
- The selective estrogen receptor modulator, raloxifene: An overview of nonclinical pharmacology and reproductive and developmental testing
- Raloxifene (LY139481 HCl) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats
- Antiestrogens. 2. Structure-activity studies in a series of 3-aroyl-2-arylbenzo[b]thiophene derivatives leading to [6- hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride (LY 156758), a remarkably effective estrogen antagonist with only minimal intrinsic estrogenicity
- Molecular basis of agonism and antagonism in the estrogen receptor
- Tamoxifen, raloxifene, and the prevention of breast cancer
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