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CAS RN: 24003-58-5 | 产品编码: Q0118
QX 314 Bromide
×
纯度/分析方法: >98.0%(T)(HPLC)
别名：
- QX 314溴化物
- 2-(2,6-二甲基苯胺基)-N,N,N-三乙基-2-氧代乙烷溴化铵
- 2-[(2,6-二甲基苯基)氨基]-N,N,N-三乙基-2-氧代乙烷-1-溴化铵
- 2-(2,6-Dimethylanilino)-N,N,N-triethyl-2-oxoethanaminium Bromide
- 2-[(2,6-Dimethylphenyl)amino]-N,N,N-triethyl-2-oxoethan-1-aminium Bromide
产品文档：
| 产品编码 | Q0118 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__6H__2__7BrN__2O = 343.31 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,湿气 (吸湿),加热 |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 24003-58-5 |
| Reaxys-RN | 3789225 |
| MDL编号 | MFCD00083182 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Precipitation Titration) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 215 °C |
GHS
相关法规
运输信息
| HS编码* | 2924.29-000 |
应用
QX 314 Bromide: A Membrane-Impermeable Sodium Channel Blocker
QX 314 bromide is a membrane-impermeable lidocaine [L0156] derivative and sodium channel blocker. QX 314 bromide has been reported to selectively block sodium channels on nociceptive neurons when delivered intracellularly through the pore of the noxious heat-sensitive TRPV1 (transient receptor potential vanilloid subfamily member 1) channel, but is ineffective when applied extracellularly.1) In addition, the combination of lidocaine (as a TRPV1 agonist) and QX-314 in an injectable formulation may be a useful adjunct for regional pain control.2,3) (The product is for research use only.)
References
- 1) Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers
- 2) The quaternary lidocaine derivative, QX-314, produces long-lasting local anesthesia in animal models in vivo
- 3) Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review
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