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CAS RN: 6591-63-5 | 产品编码: Q0010
Quinidine Sulfate Dihydrate
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| 产品编码 | Q0010 |
纯度/分析方法 
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>98.0%(T) |
| 分子式/分子量 | C__4__0H__4__8N__4O__4·H__2SO__4·2H__2O = 782.95 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| CAS RN | 6591-63-5 |
| PubChem物质ID | 87575548 |
| Merck Index (14) | 8060 |
| MDL编号 | MFCD00135926 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 80.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +268 to +280 deg(C=2, 0.1mol/L HCl) |
| Water | 4.0 to 5.0 % |
物性（参考值）
| 熔点 | 212 °C |
| 比旋光度 [α]D | 275° (C=2,0.1mol/L HCl) |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | VA5605000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2939.20-000 |
应用
Quinidine Sulfate: A Class 1a Antiarrhythmic Agent
Quinidine [Q0006], a cinchona alkaloid, originally derived from the bark of the Cinchona tree. Quinidine is a class 1a antiarrhythmic agent which interferes both with the sodium (Na+) and potassium (K+) channels, with a pharmacological profile of action similar to that of disopyramide [D2793]. Quinidine inhibits the fast inward sodium current, and depresses the conduction velocity. Consequently, quinidine decreases myocardial excitability. Its sulfate is used clinically. (The product is for research purpose only.)
References
- Quinidine (a review)
- Quinidine revisited (a review)
- Pharmacology and Toxicology of Nav1.5-Class 1 Antiarrhythmic Drugs (a review)
- Quinidine sulfate (a review on the nomenclature, physical properties, synthesis, biosynthesis, metabolism and pharmacokinetics and determination)
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