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CAS RN: 213416-70-7 | 产品编码: P3154
PIPER

产品编码 | P3154 |
纯度/分析方法 | >95.0%(HPLC) |
分子式/分子量 | C__3__8H__3__6N__4O__4 = 612.73 |
外观与形状(20°C) | 固体 |
储存温度 | 冷冻 (-20°C) |
储存在惰性气体下 | 存放于惰性气体之中 |
应避免的情况 | 空气,湿气 (分解),加热 |
CAS RN | 213416-70-7 |
Reaxys-RN | 9109510 |
MDL编号 | MFCD02179210 |
技术规格
Appearance | Red to Dark red to Dark purple powder to crystal |
Purity(HPLC) | min. 95.0 area% |
NMR | confirm to structure |
物性(参考值)
GHS
相关法规
运输信息
HS编码* | 2933.39-000 |
应用
PIPER: A Potent Telomerase Inhibitor
PIPER is a potent telomerase inhibitor used in cancer research. It inhibits human telomerase by binding to G-quadruplex DNA. Cancer cells evade replicative senescence by re-expressing telomerase, which maintains telomere length and thus chromosomal integrity. Therefore, inhibiting telomerase would cause cancer cells to senesce and thus prevent cancer cells from growing indefinitely. (The product is for research use only.)
References
- NMR-Based Model of a Telomerase-Inhibiting Compound Bound to G-Quadruplex DNA
- Accelerated Assembly of G-Quadruplex Structures by a Small Molecule
- Inhibition of Unwinding of G-Quadruplex Structures by Sgs1 Helicase in the Presence of N,N‘-Bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, a G-Quadruplex-Interactive Ligand
- Perylene diimides with different side chains are selective in inducing different G-quadruplex DNA structures and in inhibiting telomerase
- G-quadruplex DNA: a potential target for anti-cancer drug design (a review)
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