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CAS RN: 172889-27-9 | 产品编码: P2833
PP 2
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技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 210.0 to 214.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 212 °C |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | UR0717045 |
运输信息
| HS编码* | 2933.59-000 |
应用
PP2: A Potent SRC-Tyrosine Kinase Inhibitor
SRC kinase family is a family of non-receptor tyrosine kinases (Non-RTKs) that acts as a key mediator of cell signaling pathway pathways, and regulate cell adhesion, growth, and differentiation. PP2 is a potent, reversible, ATP-competitive, and selective inhibitor of the SRC family of protein tyrosine kinases.1) Therefore, PP2 has been widely used as a reagent for cancer research.2, 3) (The product is for research purpose only.)
References
- 1) Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor
- 2) Kinase inhibitors and cytotoxic drug resistance (a review)
- 3) Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor (a review)
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