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CAS RN: 198470-84-7 | 产品编码: P2579
Parecoxib
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| 产品编码 | P2579 |
纯度/分析方法 
|
>97.0%(T)(HPLC) |
| 分子式/分子量 | C__1__9H__1__8N__2O__4S = 370.42 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| CAS RN | 198470-84-7 |
| Reaxys-RN | 8640266 |
| Merck Index (14) | 7036 |
| MDL编号 | MFCD08141856 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Melting point | 153.0 to 157.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 155 °C |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H360 : May damage fertility or the unborn child. H373 : May cause damage to organs through prolonged or repeated exposure. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | TX1478700 |
运输信息
| HS编码* | 2935.90-000 |
应用
Parecoxib: A Selective Cyclooxygenase-2 (COX-2) Inhibitor
Parecoxib, a prodrug of valdecoxib [V0133], is a selective inhibitor of cyclooxygenase-2 (COX-2) which is an inducible isoform of COX. The mechanism of action is mainly by inhibition of the enzyme COX in the arachidonic acid metabolism pathway, resulting in reduced prostaglandin synthesis. In theory, a drug that selectively inhibited COX-2 might block inflammation, pain, and fever produced by prostaglandins while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1. The sodium salt is widely used for clinical. (The product is for research purpose only.)
References
- Parecoxib (parecoxib sodium)
- The second generation of COX-2 inhibitors: what advantages do the newest offer? (a review)
- Selective cyclooxygenase-2 inhibitors: similarities and differences
- Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology.
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